Regenerative Medicine and Therapeutics

Research Article Pages 46-54

Epigenetic Effects of Micronized Matrix Allograft Cartilage on Stem Cell Differentiation

Authors: Timothy Reed, BS, Taylor Mustapich, BA, Brandon Alba, MD, Haixiang Liang, MD and Daniel A Grande, PhD

Abstract: Articular cartilage injuries can lead to significant joint morbidity. Although marrow stimulation procedures such as microfracture are a popular treatment option, results are often suboptimal, with resultant neocartilage exhibiting a more fibrous than hyaline phenotype. Micronized matrix allograft cartilage has emerged as a promising adjunct to augment microfracture procedures by promoting a greater degree of hyaline cartilage regeneration and improved longterm outcomes.

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